Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.

doi:10.1016/j.jdermsci.2010.12.001

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Article

Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.

Journal of dermatological science - 1 Feb 2011

Zheng Hou-Feng, Zuo Xian-Bo, Lu Wen-Sheng, Li Yang, Cheng Hui, Zhu Kun-Ju, Yin Xian-Yong, Zhang Chi, Ren Yun-Qing, Wang Wen-Ju, Sun Liang-Dan, Cui Yong, Yang Sen, Zhang Feng-Yu, Zhang Xue-Jun

Abstract excerpt

BACKGROUND: Psoriasis has long been considered as a complex disease, and gene-gene or gene-environment interactions may jointly influence the etiology for psoriasis. OBJECTIVE: We evaluated the associations of single nucleotide polymorphisms (SNPs) in MHC region, and determined the epistasis and combined effects of MHC locus and IL12B, LCE on risk for psoriasis. METHODS: We genotyped SNP rs1265181 (MHC) in 5067...

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Identifiers

PMID: 21208785
DOI: 10.1016/j.jdermsci.2010.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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