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Article

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.

Nature - 10 Feb 2000

Bilder D, Perrimon N

Abstract excerpt

The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia, segregation of membrane proteins into apical and basolateral compartments is critical for cell morphology, tissue physiology and cell signalling. Drosophila proteins that confer apical membrane identity have been found, but the mechanisms that restrict these determinants to the apical cell...

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Identifiers

PMID: 10688207
DOI: 10.1038/35001108

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.PMID 10688207Read ↗

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Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.Semantic proximity Read ↗

Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.Semantic proximity Read ↗

A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells.Semantic proximity Read ↗

Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila.Semantic proximity Read ↗

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.Semantic proximity Read ↗

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.Semantic proximity Read ↗

Role of the Polarity Protein Scribble for Podocyte Differentiation and MaintenanceSemantic proximity Read ↗

Papillote and Piopio: Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.Semantic proximity Read ↗

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