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Article

Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.

Journal of cell science - 1 Dec 2004

Albertson Roger, Chabu Chiswili, Sheehan Amy, Doe Chris Q

Abstract excerpt

The Drosophila tumor suppressor protein Scribble is required for epithelial polarity, neuroblast polarity, neuroblast spindle asymmetry and limiting cell proliferation. It is a member of the newly described LAP protein family, containing 16 leucine rich repeats (LRRs), four PDZ domains and an extensive carboxyl-terminal (CT) domain. LRR and PDZ domains mediate protein-protein interactions, but little is know...

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Identifiers

PMID: 15536119
DOI: 10.1242/jcs.01525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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