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Article

Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2021

Lam Ying-Yiu, Tsai Sheng-Feng, Chen Pei-Chun, Kuo Yu-Min, Chen Yun-Wen

Abstract excerpt

The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of depression. Pioglitazone, a Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is widely used for treating patients with type 2 diabetes. However, whether pioglitazone alleviates metabolic disorder-related depression and astrocytic deficits remains unclear. Here we showed that 12 weeks of...

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PMID: 34022606
DOI: 10.1016/j.biopha.2021.111734

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