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Article

Endogenous ω-3 fatty acids in Fat-1 mice attenuated depression-like behaviors, spatial memory impairment and relevant changes induced by olfactory bulbectomy.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Aug 2021

Gu Minqing, Li Xiaohong, Yan Ling, Zhang Yongping, Yang Longen, Li Shurui, Song Cai

Abstract excerpt

OBJECTIVES: Olfactory bulbectomy (OB) induced behaviors, hypercortisolism, inflammation and neurotrophin dysfunctions are similar to those observed in depressed patients. Omega (n)-3 polyunsaturated fatty acids (PUFAs) can effectively treat depression via anti-inflammatory and neuroprotective effects. However, n-3 PUFA purities, caloric contents, and ratios in different diets often cause contradictive results....

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Source

Identifiers

PMID: 34246927
DOI: 10.1016/j.plefa.2021.102313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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