Article

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth in High-Fat Diet Mice and Neurons Under Metabolic Imbalance Conditions

2020-11-24

Abstract excerpt

Metabolic syndrome, which increases the risk of obesity and type 2 diabetes, has emerged as a significant issue worldwide. Metabolic syndrome can occur due to diverse factors such as genetic background, lifestyle changes, food intake, and aging. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies, such as synaptic dysfunction and memory loss. Glucagon-like pept...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9342e44b-9cf3-5396-a1e6-5826452ce81b
DOI: 10.21203/rs.3.rs-109387/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth in High-Fat Diet Mice and Neurons Under Metabolic Imbalance ConditionsDOI 10.21203/rs.3.rs-109387/v1Read

Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s diseaseSemantic proximity Read

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3aSemantic proximity Read

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapySemantic proximity Read

Altered cognitive function in obese patients: relationship to gut floraSemantic proximity Read

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the HypothalamusSemantic proximity Read

Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice.Semantic proximity Read

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.Semantic proximity Read

Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the BrainSemantic proximity Read

Metformin acts directly in the brain to slow features of neurodegenerationSemantic proximity Read

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesisSemantic proximity Read

Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acidSemantic proximity Read

Dual Role of Neuroplastin in Pancreatic β Cells: Regulating Insulin Secretion and Promoting Islet InflammationSemantic proximity Read