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Article

Circulating HDL levels control hypothalamic astrogliosis via apoA-I.

Journal of lipid research - 1 Sept 2018

Götz Anna, Lehti Maarit, Donelan Elizabeth, Striese Cynthia, Cucuruz Sebastian, Sachs Stephan, Yi Chun-Xia, Woods Stephen C, Wright Samuel D, Müller Timo D, Tschöp Matthias H, Gao Yuanqing, Hofmann Susanna M

Abstract excerpt

Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced neuronal injury triggers microgliosis and astrocytosis, conditions which ultimately may induce functional impairment of hypothalamic circuits governing feeding...

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Share to Adenosine Triphosphate
Share to Apolipoprotein A-I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipoproteins, HDL

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Source

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Identifiers

PMID: 29991652
DOI: 10.1194/jlr.M085456
PMCID: PMC6121940

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