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Mutant KRAS in Circulating Tumor DNA as a Biomarker in Localized Pancreatic Cancer Patients Treated With Neoadjuvant Chemotherapy.

Annals of surgery - 1 Jul 2026

Vitello Dominic J, Shah Dhavan, Wells Amy, Masnyk Larissa, Cox Madison, Janczewski Lauren M, Abad John, Dawravoo Kevin, D'Souza Arlene, Suh Grace, Bayer Robert, Cristofanilli Massimo, Bentrem David, Liu Yingzhe, Zhang Hui, Santana-Santos Lucas, Jennings Lawrence J, Zhang Qiang, Chawla Akhil

Abstract excerpt

OBJECTIVE: The primary objective was to determine the prognostic significance of circulating tumor DNA (ctDNA) in patients receiving neoadjuvant chemotherapy (NAC) for localized pancreatic ductal adenocarcinoma (PDAC) using digital droplet polymerase chain reaction (ddPCR). BACKGROUND: Increasingly, ctDNA is being used for clinical decision-making in a variety of solid malignancies. However, the detection and...

Topics

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Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
Circulating Tumor DNA
Neoadjuvant Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Polymerase Chain Reaction

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 39471087
DOI: 10.1097/SLA.0000000000006562

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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