High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

doi:10.1158/1078-0432.CCR-26-0609

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Article

High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2026

Sridalla Krishay, Machhi Jasmine K, Vitello Dominic J, Chibucos Anastasia, Cox Madison, Wells Amy, Horowitz Alex, Rengaraju Vishvetha, Shen Claire, Romero Nicole, Temosihue Isabel, Janczewski Lauren M, Abad John, Dawravoo Kevin, Bentrem David, Jennings Lawrence J, Zhang Qiang, Chawla Akhil

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) carries high mortality despite multimodal therapy, and improved biomarkers are needed to guide perioperative care. This study evaluated the prognostic significance of Kirsten rat sarcoma virus (KRAS)-mutant circulating tumor DNA (ctDNA) detected by next-generation sequencing (NGS) and digital droplet PCR (ddPCR) in localized PDAC. EXPERIMENTAL DESIGN: In this...

Read the complete abstract on PubMed

Topics

Humans
Circulating Tumor DNA
Pancreatic Neoplasms
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Carcinoma, Pancreatic Ductal

Prognosis

Biomarkers, Tumor

Proto-Oncogene Proteins p21(ras)

Male

Prospective Studies

Mutation

Aged

Middle Aged

Neoadjuvant Therapy

Source

Open in PubMed Open full text

Identifiers

PMID: 42377115
DOI: 10.1158/1078-0432.CCR-26-0609
PMCID: PMC13405252

Genes

KRAS

Variants

Provenance

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