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Article

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer.

Nature reviews. Gastroenterology & hepatology - 1 Mar 2020

Buscail Louis, Bournet Barbara, Cordelier Pierre

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common cause of death within the next 10 years. The prognosis for this disease is poor despite diagnostic progress and new chemotherapeutic regimens. The oncogenic KRAS mutation is the major event in pancreatic cancer; it confers permanent activation of the KRAS protein, which acts as a molecular switch to activate various intracellular...

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PMID: 32005945
DOI: 10.1038/s41575-019-0245-4

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