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Article

Strand Orientation Bias Detector to determine the probability of FFPE sequencing artifacts.

Briefings in bioinformatics - 5 Nov 2021

Diossy Miklos, Sztupinszki Zsofia, Krzystanek Marcin, Borcsok Judit, Eklund Aron C, Csabai István, Pedersen Anders Gorm, Szallasi Zoltan

Abstract excerpt

Formalin-fixed paraffin-embedded tissue, the most common tissue specimen stored in clinical practice, presents challenges in the analysis due to formalin-induced artifacts. Here, we present Strand Orientation Bias Detector (SOBDetector), a flexible computational platform compatible with all the common somatic SNV-calling pipelines, designed to assess the probability whether a given detected mutation is an...

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PMID: 34015811
DOI: 10.1093/bib/bbab186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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