Article

An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding

2026-03-13

Abstract excerpt

<h4>Background</h4> Formalin-fixed paraffin-embedding (FFPE) is a widely used, cost-effective method for long-term storage of clinical samples. However, fixation is known to introduce damage to nucleic acids that can present as artifactual bases in sequencing otherwise absent from higher fidelity storage methods such as fresh freezing (FF). Various machine learning methods exist for filtering these variant artifa...

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Literature Corpus work: b76b0f1f-314c-53d4-b44d-0fdb4143a179
DOI: 10.64898/2026.03.10.710815

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