Article

Reducing artifactual somatic variant calls from formalin-fixed paraffin-embedded specimens by using DEEPOMICSⓇ FFPE, a bioinformatic approach based on deep neural networks

2023-06-22

Abstract excerpt

<title>Abstract</title> <p> Formalin-fixed, paraffin-embedded (FFPE) tissue specimens are routinely used in pathological diagnosis, but their large number of artifactual mutations complicate the evaluation of companion diagnostics and analysis of next-generation sequencing data. Identification of variants with low allele frequencies is challenging because existing FFPE filtering tools label all low-frequency var...

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Literature Corpus work: de8cdab5-47af-589e-be37-88406c53bb37
DOI: 10.21203/rs.3.rs-2922419/v2

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