Article
Primed CRISPR-Cas Adaptation and Impaired Phage Adsorption in Streptococcus mutans.
mSphere - 19 May 2021
Mosterd Cas, Moineau Sylvain
Abstract excerpt
Streptococcus mutans strain P42S possesses a type II-A CRISPR-Cas system that protects against phage infection and plasmid transformation. The analysis of 293 bacteriophage-insensitive mutants (BIMs) obtained upon exposure to the virulent phage M102AD revealed the acquisition of 399 unique spacers, including several ectopic spacer acquisitions and a few cases of native spacer deletions. The acquisition of...
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