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Article

CFTR function and clinical response to modulators parallel nasal epithelial organoid swelling.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2021

Anderson Justin D, Liu Zhongyu, Odom L Victoria, Kersh Latona, Guimbellot Jennifer S

Abstract excerpt

In vitro biomarkers to assess cystic fibrosis transmembrane conductance regulator activity are desirable for precision modulator selection and as a tool for clinical trials. Here, we describe an organoid swelling assay derived from human nasal epithelia using commercially available reagents and equipment and an automated imaging process. Cells were collected in nasal brush biopsies, expanded in vitro, and...

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Identifiers

PMID: 34009038
DOI: 10.1152/ajplung.00639.2020
PMCID: PMC8321858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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