Article
Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients.
Journal of visualized experiments : JoVE - 11 Feb 2017
Boj Sylvia F, Vonk Annelotte M, Statia Marvin, Su Jinyi, Vries Robert R G, Beekman Jeffrey M, Clevers Hans
Abstract excerpt
Recently-developed cystic fibrosis transmembrane conductance regulator (CFTR)-modulating drugs correct surface expression and/or function of the mutant CFTR channel in subjects with cystic fibrosis (CF). Identification of subjects that may benefit from these drugs is challenging because of the extensive heterogeneity of CFTR mutations, as well as other unknown factors that contribute to individual drug efficacy....
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