Article

Forskolin-induced swelling of intestinal organoids predicts long-term cystic fibrosis disease progression

2021-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived organoids hold great potential as predictive biomarker for disease expression or therapeutic response. Here, we used intestinal organoids to estimate individual cystic fibrosis transmembrane conductance regulator (CFTR) function of people with cystic fibrosis, a monogenic life-shortening disease associated with more than 2000 CFTR mutations and highly variable disease progression....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec71191b-46b8-55d5-9dd9-96599544947d
DOI: 10.1101/2021.02.01.21250609

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Forskolin-induced swelling of intestinal organoids predicts long-term cystic fibrosis disease progressionDOI 10.1101/2021.02.01.21250609Read

Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.Semantic proximity Read

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients.Semantic proximity Read

Correction of CFTR function in intestinal organoids to guide treatment of cystic fibrosis.Semantic proximity Read

Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations.Semantic proximity Read

Forskolin induced swelling (FIS) assay in intestinal organoids to guide eligibility for compassionate use treatment in a CF patient with a rare genotype.Semantic proximity Read

FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis GenotypesSemantic proximity Read

Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models.Semantic proximity Read

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis.Semantic proximity Read

Targeted locus amplification reveals heterogeneity between and within CFTR genotypes and association with CFTR function in patient-derived intestinal organoids.Semantic proximity Read

Airway and lung organoids from human induced pluripotent stem cells can be used to assess CFTR conductanceSemantic proximity Read

CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes.Semantic proximity Read

FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes.Semantic proximity Read