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Article

Nasospheroids permit measurements of CFTR-dependent fluid transport.

JCI insight - 16 Nov 2017

Guimbellot Jennifer S, Leach Justin M, Chaudhry Imron G, Quinney Nancy L, Boyles Susan E, Chua Michael, Aban Inmaculada, Jaspers Ilona, Gentzsch Martina

Abstract excerpt

Expansion of novel therapeutics to all patients with cystic fibrosis (CF) requires personalized CFTR modulator therapy. We have developed nasospheroids, a primary cell culture-based model derived from individual CF patients and healthy subjects by a minimally invasive nasal biopsy. Confocal microscopy was utilized to measure CFTR activity by analyzing changes in cross-sectional area over time that resulted from...

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Source

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Identifiers

PMID: 29202459
DOI: 10.1172/jci.insight.95734
PMCID: PMC5752372

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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