Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis.

Scientific reports - 30 Jul 2021

Calucho Maite, Gartner Silvia, Barranco Paula, Fernández-Álvarez Paula, Pérez Raquel García, Tizzano Eduardo F

Abstract excerpt

The availability of a simple, robust and non-invasive in vitro airway model would be useful to study the functionality of the cystic fibrosis transmembrane regulator (CFTR) protein and to personalize modulator therapy for cystic fibrosis (CF) patients. Our aim was to validate a CFTR functional study using nasospheroids, a patient-derived nasal cell 3D-culture. We performed live-cell experiments in nasospheroids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Genotype

Share to Respiratory System

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 34330959
DOI: 10.1038/s41598-021-94798-x
PMCID: PMC8324871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis.PMID 34330959Read ↗

Nasospheroids permit measurements of CFTR-dependent fluid transport.Semantic proximity Read ↗

Detection of CFTR function and modulation in primary human nasal cell spheroids.Semantic proximity Read ↗

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis.Semantic proximity Read ↗

CFTR function and clinical response to modulators parallel nasal epithelial organoid swelling.Semantic proximity Read ↗

CFTR Modulator Response in Nasal Organoids Derived from People with Cystic Fibrosis.Semantic proximity Read ↗

Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoidsSemantic proximity Read ↗

Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic FibrosisSemantic proximity Read ↗

Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defectSemantic proximity Read ↗

β2-Adrenergic receptor agonists activate CFTR in intestinal organoids and subjects with cystic fibrosis.Semantic proximity Read ↗

Phenotypic profiling of CFTR modulators in patient-derived respiratory epitheliaSemantic proximity Read ↗

High-Throughput Functional Assay in Cystic Fibrosis Patient-Derived Organoids Allows Drug RepurposingSemantic proximity Read ↗

Correlation of Electrophysiological and Fluorescence-Based Measurements of Modulator Efficacy in Nasal Epithelial Cultures Derived from People with Cystic Fibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.