Article
β2-Adrenergic receptor agonists activate CFTR in intestinal organoids and subjects with cystic fibrosis.
The European respiratory journal - 1 Sept 2016
Vijftigschild Lodewijk A W, Berkers Gitte, Dekkers Johanna F, Zomer-van Ommen Domenique D, Matthes Elizabeth, Kruisselbrink Evelien, Vonk Annelotte, Hensen Chantal E, Heida-Michel Sabine, Geerdink Margot, Janssens Hettie M, van de Graaf Eduard A, Bronsveld Inez, de Winter-de Groot Karin M, Majoor Christof J, Heijerman Harry G M, de Jonge Hugo R, Hanrahan John W, van der Ent Cornelis K, Beekman Jeffrey M
Abstract excerpt
We hypothesized that people with cystic fibrosis (CF) who express CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations associated with residual function may benefit from G-protein coupled receptor (GPCR)-targeting drugs that can activate and enhance CFTR function.We used intestinal organoids to screen a GPCR-modulating compound library and identified β2-adrenergic receptor agonists as the...
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