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Article

Detection of CFTR function and modulation in primary human nasal cell spheroids.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2018

Brewington John J, Filbrandt Erin T, LaRosa F J, Ostmann Alicia J, Strecker Lauren M, Szczesniak Rhonda D, Clancy John P

Abstract excerpt

BACKGROUND: Expansion of CFTR modulators to patients with rare/undescribed mutations will be facilitated by patient-derived models quantifying CFTR function and restoration. We aimed to generate a personalized model system of CFTR function and modulation using non-surgically obtained nasal epithelial cells (NECs). METHODS: NECs obtained by curettage from healthy volunteers and CF patients were expanded and grown...

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Source

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Identifiers

PMID: 28712885
DOI: 10.1016/j.jcf.2017.06.010
PMCID: PMC5868354

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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