Article
Rare codons regulate KRas oncogenesis.
Current biology : CB - 7 Jan 2013
Lampson Benjamin L, Pershing Nicole L K, Prinz Joseph A, Lacsina Joshua R, Marzluff William F, Nicchitta Christopher V, MacAlpine David M, Counter Christopher M
Abstract excerpt
Oncogenic mutations in the small Ras GTPases KRas, HRas, and NRas render the proteins constitutively GTP bound and active, a state that promotes cancer. Ras proteins share ~85% amino acid identity, are activated by and signal through the same proteins, and can exhibit functional redundancy. Nevertheless, manipulating expression or activation of each isoform yields different cellular responses and tumorigenic...
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