Article

p53 dosage impedes Kras <sup>G12D</sup> - and Kras <sup>Q61R</sup> -mediated tumorigenesis

2023-09-17

Abstract excerpt

Mice engineered with G12D versus Q61R mutant of Kras exhibit differences in the number and grade of tumors. Namely, the incidence or grade of oral or forestomach squamous epithelial lesions was more prevalent in the Kras G12D background while hematolymphopoietic disease was more prevalent in the Kras Q61R background. Loss of the Trp53 gene encoding p53 enhances the ability of oncogenic Kras to initiate tumorige...

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Literature Corpus work: 7a1cf81a-2c87-53bd-a1d5-9b019d36182a
DOI: 10.1101/2023.09.17.558140

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