Article
Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS.
PloS one - 1 Jan 2011
Zhang Yi, Wheatley Randi, Fulkerson Eric, Tapp Amanda, Estes Patricia A
Abstract excerpt
BACKGROUND: The Notch pathway functions repeatedly during the development of the central nervous system in metazoan organisms to control cell fate and regulate cell proliferation and asymmetric cell divisions. Within the Drosophila midline cell lineage, which bisects the two symmetrical halves of the central nervous system, Notch is required for initial cell specification and subsequent differentiation of many...
Topics
- Animals
- Cell Lineage
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Embryonic Development
- Mutation
- Nuclear Proteins
- Receptors, Notch
- Signal Transduction