Article
Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.
Developmental biology - 15 Nov 1999
Helms W, Lee H, Ammerman M, Parks A L, Muskavitch M A, Yedvobnick B
Abstract excerpt
The phenotypes and genetic interactions associated with mutations in the Drosophila mastermind (mam) gene have implicated it as a component of the Notch signaling pathway. However, its function and site of action within many tissues requiring Notch signaling have not been thoroughly investigated. To address these questions, we have constructed truncated versions of the Mam protein that elicit dominant phenotypes...
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