Identification of a shared genetic risk locus for Kawasaki disease and immunoglobulin A vasculitis by a cross-phenotype meta-analysis.

doi:10.1093/rheumatology/keab443

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Article

Identification of a shared genetic risk locus for Kawasaki disease and immunoglobulin A vasculitis by a cross-phenotype meta-analysis.

Rheumatology (Oxford, England) - 2 Mar 2022

Carmona Elio G, García-Giménez Jose A, López-Mejías Raquel, Khor Chiea Chuen, Lee Jong-Keuk, Taskiran Ekim, Ozen Seza, Hocevar Alojzija, Liu Lili, Gorenjak Mario, Potočnik Uroš, Kiryluk Krzysztof, Ortego-Centeno Norberto, Cid María C, Hernández-Rodríguez José, Castañeda Santos, González-Gay Miguel A, Burgner David, Martín Javier, Márquez Ana

Abstract excerpt

OBJECTIVES: Combining of genomic data of different pathologies as a single phenotype has emerged as a useful strategy to identify genetic risk loci shared among immune-mediated diseases. Our study aimed to increase our knowledge of the genetic contribution to Kawasaki disease (KD) and IgA vasculitis (IgAV) by performing the first comprehensive large-scale analysis on the genetic overlap between them. METHODS: A...

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PMID: 33993232
DOI: 10.1093/rheumatology/keab443
PMCID: PMC10687354

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