A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.

doi:10.1038/s41598-017-03915-2

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Article

A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.

Scientific reports - 11 Jul 2017

López-Mejías Raquel, Carmona F David, Castañeda Santos, Genre Fernanda, Remuzgo-Martínez Sara, Sevilla-Perez Belén, Ortego-Centeno Norberto, Llorca Javier, Ubilla Begoña, Mijares Verónica, Pina Trinitario, Miranda-Filloy José A, Navas Parejo Antonio, de Argila Diego, Aragües Maximiliano, Rubio Esteban, Luque Manuel León, Blanco-Madrigal Juan María, Galíndez-Aguirregoikoa Eva, Jayne David, Blanco Ricardo, Martín Javier, González-Gay Miguel A

Abstract excerpt

The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000...

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PMID: 28698626
DOI: 10.1038/s41598-017-03915-2
PMCID: PMC5506002

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