Article
Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy.
Scientific reports - 9 Mar 2017
Carmona F David, Coit Patrick, Saruhan-Direskeneli Güher, Hernández-Rodríguez José, Cid María C, Solans Roser, Castañeda Santos, Vaglio Augusto, Direskeneli Haner, Merkel Peter A, Boiardi Luigi, Salvarani Carlo, González-Gay Miguel A, Martín Javier, Sawalha Amr H
Abstract excerpt
Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II...
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