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PP1, PKA and DARPP‐32 in breast cancer: A retrospective assessment of protein and mRNA expression

15 May 2021

Abstract excerpt

Cyclic AMP-dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine- and cAMP-regulated phosphoprotein 32 kD (DARPP-32). Using immunohistochemistry, PKA and PP1 expression was determined in a large primary breast tumour cohort to evaluate...

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PMID: 33991172
DOI: 10.1111/jcmm.16447

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