Article

Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways

2023-06-13

Abstract excerpt

DARPP-32 is a key regulator of protein-phosphatase-1 (PP-1) and protein kinase A (PKA), with its function dependent upon its phosphorylation state. We previously identified DKK1 and GRB7 as genes with linked expression using Artificial Neural Network (ANN) analysis; here, we determine protein expression in a large cohort of early-stage breast cancer patients. Low levels of DARPP-32 Threonine-34 phosphorylation and...

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Literature Corpus work: 86655b3d-0fe7-51b9-a134-fcb5fe526165
DOI: 10.21203/rs.3.rs-3029600/v1

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