Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of Protein Kinase A Regulation Causes Immortalization and Dysregulation of D-Type Cyclins

15 Nov 2005

Abstract excerpt

Phosphorylation is a key event in cell cycle control, and dysregulation of this process is observed in many tumors, including those associated with specific inherited neoplasia syndromes. We have shown previously that patients with the autosomal dominant tumor predisposition Carney complex carry inactivating mutations in the PRKAR1A gene, which encodes the type 1A regulatory subunit of protein kinase A (PKA), the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Sarcoma Diagnosis and Treatment
Share to Soft tissue tumor case studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16288019
DOI: 10.1158/0008-5472.can-05-3183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of Protein Kinase A Regulation Causes Immortalization and Dysregulation of D-Type CyclinsPMID 16288019Read ↗

Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/− or Rb1+/− backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signalingSemantic proximity Read ↗

Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2.Semantic proximity Read ↗

PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.Semantic proximity Read ↗

Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex.Semantic proximity Read ↗

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other TumorsSemantic proximity Read ↗

Minireview: PRKAR1A: Normal and Abnormal FunctionsSemantic proximity Read ↗

Proliferation of Transformed Somatotroph Cells Related to Low or Absent Expression of Protein Kinase A Regulatory Subunit 1A ProteinSemantic proximity Read ↗

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.Semantic proximity Read ↗

Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency.Semantic proximity Read ↗

Protein kinase A and its role in human neoplasia: the Carney complex paradigm.Semantic proximity Read ↗

Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.Semantic proximity Read ↗

Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.