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Article

PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.

The Journal of clinical endocrinology and metabolism - 1 Jun 2006

Robinson-White Audrey, Meoli Elise, Stergiopoulos Sotirios, Horvath Anelia, Boikos Sosipatros, Bossis Ioannis, Stratakis Constantine A

Abstract excerpt

CONTEXT: Primary pigmented nodular adrenocortical disease, associated with Carney complex, is caused by mutations in PRKAR1A (mt-PRKAR1A), a gene that codes for the regulatory subunit type 1alpha (RIalpha) of cAMP-dependent protein kinase (PKA). PRKAR1A inactivation is associated with dysregulated PKA activity that is thought to result in tumorigenesis. mt-PRKAR1A-bearing lymphocytes from Carney complex patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16569736
DOI: 10.1210/jc.2006-0188

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PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.PMID 16569736Read ↗

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Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.Semantic proximity Read ↗

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