Article
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia.
The Journal of clinical endocrinology and metabolism - 1 Sept 2006
Bourdeau Isabelle, Matyakhina Ludmila, Stergiopoulos Sotirios G, Sandrini Fabiano, Boikos Sosipatros, Stratakis Constantine A
Abstract excerpt
CONTEXT: Primary adrenocortical hyperplasias leading to Cushing syndrome include primary pigmented nodular adrenocortical disease and ACTH-independent macronodular adrenal hyperplasia (AIMAH). Inactivating mutations of the 17q22-24-located PRKAR1A gene, coding for the type 1A regulatory subunit of protein kinase A (PKA), cause primary pigmented nodular adrenocortical disease and the multiple endocrine neoplasia...
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