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HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

14 May 2021

Abstract excerpt

POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells. Here, we identified the CRC-specific gene, HNF1A, which is the downstream of POU5F1. HNF1A associates with fatty acid and glucose metabolism, and CRC cells highly expressed it. In 198 CRC patients, high HNF1A expression was an...

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PMID: 33990627
DOI: 10.1038/s41598-021-89126-2

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