Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1

14 Dec 2023

Abstract excerpt

CircRNAs are implicated in colorectal cancer (CRC) development and progression. Protein O-fucosyltransferase 1 (POFUT1) plays an oncogenic role via activating Notch1 signaling in CRC. However, the roles of circPOFUT1, which is originated from POFUT1, have not been investigated. Our study showed circPOFUT1 was highly expressed in CRC tissues and cells. CircPOFUT1 enhanced the proliferation, migration and invasion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Circular RNAs in diseases
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38230259
DOI: 10.1016/j.isci.2023.108729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1PMID 38230259Read ↗

Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of <i>POFUT1</i> expression in colon cancerSemantic proximity Read ↗

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.Semantic proximity Read ↗

FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancerSemantic proximity Read ↗

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesisSemantic proximity Read ↗

lncRNA TUG1 Facilitates Colorectal Cancer Stem Cell Characteristics and Chemoresistance by Enhancing GATA6 Protein StabilitySemantic proximity Read ↗

CircDIAPH1 Promotes Liver Metastasis and Development of Colorectal Cancer by Initiation of CEACAM6 ExpressionSemantic proximity Read ↗

miR-133b suppresses colorectal cancer cell stemness and chemoresistance by targeting methyltransferase DOT1LSemantic proximity Read ↗

PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemnessSemantic proximity Read ↗

Circular RNA PGPEP1 induces colorectal cancer malignancy and immune escapeSemantic proximity Read ↗

Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs.Semantic proximity Read ↗

Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 StabilizationSemantic proximity Read ↗

The interaction between long non-coding RNA LINC01564 and POU2F1 promotes the proliferation and metastasis of gastric cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.