Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

doi:10.1038/s41589-020-0578-x

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Article

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

Nature chemical biology - 1 Oct 2020

Osterman Ilya A, Wieland Maximiliane, Maviza Tinashe P, Lashkevich Kseniya A, Lukianov Dmitrii A, Komarova Ekaterina S, Zakalyukina Yuliya V, Buschauer Robert, Shiriaev Dmitrii I, Leyn Semen A, Zlamal Jaime E, Biryukov Mikhail V, Skvortsov Dmitry A, Tashlitsky Vadim N, Polshakov Vladimir I, Cheng Jingdong, Polikanov Yury S, Bogdanov Alexey A, Osterman Andrei L, Dmitriev Sergey E, Beckmann Roland, Dontsova Olga A, Wilson Daniel N, Sergiev Petr V

Abstract excerpt

The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of clinically used antibiotics obsolete, highlighting the urgent need for new lead compounds with distinct target binding sites to avoid cross-resistance. Here we report that the aromatic polyketide antibiotic tetracenomycin (TcmX) is a potent inhibitor of protein synthesis, and does not induce DNA damage as previously thought....

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PMID: 32601485
DOI: 10.1038/s41589-020-0578-x

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