Article

WWP2 osteoarthritis risk allele rs1052429-A confers risk by affecting cartilage matrix deposition via hypoxia associated genes

2022-03-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> To explore the co-expression network of the osteoarthritis (OA) risk gene WWP2 in articular cartilage and study cartilage characteristics when mimicking the effect of OA risk allele rs1052429-A on WWP2 expression in a human 3D in vitro model of cartilage. <h4>Methods</h4> Co-expression behavior of WWP2 with genes expressed in lesioned OA articular cartilage (N=35 sample...

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Literature Corpus work: c2e9e597-68a2-5694-a500-4ac76adc9390
DOI: 10.1101/2022.03.31.486523

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