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Article

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

26 Jul 2013

Abstract excerpt

Oxidative stress induced by reactive oxygen species can result in DNA damage within cells and subsequently increase risk for carcinogenesis. This may be averted by repair of DNA damage through the base or nucleotide excision repair (BER/NER) pathways. PARP, a BER protein, is known for its role in DNA-repair. However, multiple lesions can occur within a small range of DNA, known as oxidative clustered DNA lesions...

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PMID: 24202328
DOI: 10.3390/cancers5030943

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