Article
Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Nature communications - 12 May 2021
Wurm Jan Philip, Sung Sihyun, Kneuttinger Andrea Christa, Hupfeld Enrico, Sterner Reinhard, Wilmanns Matthias, Sprangers Remco
Abstract excerpt
Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is allosterically regulated but the underlying mechanism is not well understood. Here, we elucidate the molecular basis...
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