Article
Subunit interactions and glutamine utilization by Escherichia coli imidazole glycerol phosphate synthase.
Journal of bacteriology - 1 Feb 2001
Klem T J, Chen Y, Davisson V J
Abstract excerpt
A selection strategy has been developed to identify amino acid residues involved in subunit interactions that coordinate the two half-reactions catalyzed by glutamine amidotransferases. The protein structures known for this class of enzymes have revealed that ammonia is shuttled over long distances and that each amidotransferase evolved different molecular tunnels for this purpose. The heterodimeric Escherichia...
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