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Article

Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multienzyme complex.

Structure (London, England : 1993) - 10 Dec 2008

Pei Xue Yuan, Titman Christopher M, Frank René A W, Leeper Finian J, Luisi Ben F

Abstract excerpt

The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a nexus of central metabolism. We report crystal structures of the Geobacillus stearothermophilus PDH E1p subunit with ligands that mimic the...

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Identifiers

PMID: 19081062
DOI: 10.1016/j.str.2008.10.009
PMCID: PMC2663715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19081062-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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