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Article

Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multienzyme complex.

Structure (London, England : 1993) - 10 Dec 2008

Pei Xue Yuan, Titman Christopher M, Frank René A W, Leeper Finian J, Luisi Ben F

Abstract excerpt

The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a nexus of central metabolism. We report crystal structures of the Geobacillus stearothermophilus PDH E1p subunit with ligands that mimic the prereaction complex and the postdecarboxylation product. The structures implicate residues that help to orient...

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Identifiers

PMID: 19081062
DOI: 10.1016/j.str.2008.10.009
PMCID: PMC2663715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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