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Article

The pyrin domain of IFI16 forms a distinct filament structure important for IFI16-mediated enhancement of STING activation.

Structure (London, England : 1993) - 2 Apr 2026

Takahashi Ryuichi, Zhang Zhikuan, Fujimura Akiko, Ohto Umeharu, Shimizu Toshiyuki

Abstract excerpt

Interferon-gamma inducible protein 16 (IFI16) is a member of the HIN-200 family and has been proposed as a pathogenic DNA sensor with the dual function of activating both the inflammasome pathway and the stimulator of interferon genes (STING) pathway. Here, our cryo-EM analysis revealed that the pyrin domain (PYD) of IFI16 self-oligomerizes into a filamentous structure. The filament structure of IFI16PYD is...

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Source

Identifiers

PMID: 41720081
DOI: 10.1016/j.str.2026.01.011

Genes

IFI16
AIM2
C3
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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