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Article

DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends.

Nucleic acids research - 18 Mar 2020

Bonetti Diego, Rinaldi Carlo, Vertemara Jacopo, Notaro Marco, Pizzul Paolo, Tisi Renata, Zampella Giuseppe, Longhese Maria Pia

Abstract excerpt

The cellular response to DNA double-strand breaks (DSBs) is initiated by the Mre11-Rad50-Xrs2 (MRX) complex that has structural and catalytic functions. MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that binds telomeric DNA through two tandem Myb-like domains. Whether and how Rap1 acts at DSBs is unknown. Here we show that Rif2 inhibits MRX association to DSBs in a manner...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31879780
DOI: 10.1093/nar/gkz1203
PMCID: PMC7049697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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