Article

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

2025-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Bipolar disorder’s (BD) clinical heterogeneity has an unresolved genetic basis. We meta-analyzed genome-wide association studies (GWAS) of 16 BD subphenotypes in 226,032 individuals from 57 cohorts (38,022 cases); 10 advanced to multivariate and multi-trait analyses. Four factors (compulsive, psychotic, dysregulated, internalizing) explained 82.8% of shared genetic variance. BD1 and BD2 loaded o...

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Literature Corpus work: c17b6c5e-1d90-54c2-9cf0-a6355af717c3
DOI: 10.1101/2025.06.23.25330155

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