Article

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

2026-08-26

Abstract excerpt

<title>Abstract</title> <p>Bipolar disorder's (BD) clinical heterogeneity has an unresolved genetic basis. We meta-analyzed genome-wide association studies (GWAS) of 16 BD subphenotypes in 226,032 individuals from 57 cohorts (38,022 cases); 10 advanced to multivariate and multi-trait analyses. Four factors (compulsive, psychotic, dysregulated, internalizing) explained 82.8% of shared genetic variance. BD1 and BD2...

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Literature Corpus work: dc4677f2-6d25-5232-a99b-f55c6fdfb921
DOI: 10.21203/rs.3.rs-10041361/v1

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