Article
Young proteins experience more variable selection pressures than old proteins.
Genome research - 1 Nov 2010
Vishnoi Anchal, Kryazhimskiy Sergey, Bazykin Georgii A, Hannenhalli Sridhar, Plotkin Joshua B
Abstract excerpt
It is well known that young proteins tend to experience weaker purifying selection and evolve more quickly than old proteins. Here, we show that, in addition, young proteins tend to experience more variable selection pressures over time than old proteins. We demonstrate this pattern in three independent taxonomic groups: yeast, Drosophila, and mammals. The increased variability of selection pressures on young...
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