Article

On the regulatory evolution of new genes throughout their life history

2018-03-05

Abstract excerpt

Every gene has a birthplace and an age, i.e., a cis-regulatory environment and an evolution lifespan since its origination, yet how gene’s evolution trajectory is shaped by the two remains unclear. Here we address this basic question by comparing phylogenetically dated new genes of different ages among Drosophila and vertebrate species. For both, we find a clear ‘out of testis’ transition from the testis-specific...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8cb90209-bf80-53ed-ba7d-1e62c22c0ab5
DOI: 10.1101/276667

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

On the regulatory evolution of new genes throughout their life historyDOI 10.1101/276667Read

On the origin and evolution of <i>Drosophila</i> new genes during spermatogenesisSemantic proximity Read

Origins, evolution, and phenotypic impact of new genes.Semantic proximity Read

Testis single-cell RNA-seq reveals the dynamics of <i>de novo</i> gene transcription and germline mutational bias in <i>Drosophila</i>Semantic proximity Read

Molecular evolution and the decline of purifying selection with age.Semantic proximity Read

Improved sampling of genotypes and species reveals new insights on de novo gene history and regulatory origins.Semantic proximity Read

Mammalian housekeeping genes evolve more slowly than tissue-specific genes.Semantic proximity Read

Redefining Housekeeping Genes in the Context of Vertebrate DevelopmentSemantic proximity Read

New genes as drivers of phenotypic evolution.Semantic proximity Read

Functional innovation through new genes as a general evolutionary process.Semantic proximity Read

Polymorphism and Divergence of Novel Gene Expression Patterns in Drosophila melanogaster.Semantic proximity Read

Evolutionary analysis of gene ages across TADs associates chromatin topology with whole genome duplicationsSemantic proximity Read

Gene age predicts the strength of purifying selection acting on gene expression variation in humans.Semantic proximity Read