Article
Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles.
Diabetes - 1 Aug 2021
Noordam Raymond, Läll Kristi, Smit Roelof A J, Laisk Triin, Metspalu Andres, Esko Tõnu, Milani Lili, Loos Ruth J F, Mägi Reedik, Willems van Dijk Ko, van Heemst Diana
Abstract excerpt
The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we used a stratification based on age of diagnosis to gain insight into the genetics and causal risk factors of T2D across different age-groups. We performed genome-wide association studies (GWAS) on T2D and T2D subgroups based on age of diagnosis (<50, 50-60, 60-70, and >70 years) (total of 24,986 cases). As control subjects,...
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