Article
Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity.
Human molecular genetics - 7 Aug 2023
Christiansen Colette E, Arathimos Ryan, Pain Oliver, Molokhia Mariam, Bell Jordana T, Lewis Cathryn M
Abstract excerpt
Type 2 diabetes (T2D) is a heterogeneous illness caused by genetic and environmental factors. Previous genome-wide association studies (GWAS) have identified many genetic variants associated with T2D and found evidence of differing genetic profiles by age-at-onset. This study seeks to explore further the genetic and environmental drivers of T2D by analyzing subgroups on the basis of age-at-onset of diabetes and...
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