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Article

Choice of β-Lactam Resistance Pathway Depends Critically on Initial Antibiotic Concentration.

Antimicrobial agents and chemotherapy - 16 Jul 2021

Ruelens Philip, de Visser J Arjan G M

Abstract excerpt

Antibiotic resistance trajectories with different final resistance may critically depend on the first mutation, due to epistatic interactions. Here, we study the effect of mutation bias and the concentration-dependent effects on fitness of two clinically important mutations in TEM-1 β-lactamase in initiating alternative trajectories to cefotaxime resistance. We show that at low cefotaxime concentrations, the...

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Identifiers

PMID: 33972257
DOI: 10.1128/AAC.00471-21
PMCID: PMC8284463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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